Chemical etiology of nucleic acid structure.

Synthesis of Nitrogen Functional Derivatives of 5-substituted-6-azauracil as one of the Four Nucleobases in the Nucleic Acid of RNA

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoateshave been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides.Reactions ofthe 3-arylhydrazono-2,4-dioxo-4-phenylbutanoateswith 1-aminoguanidine, semicarbazide, and thiosemicarbazidegave5-substituted 2-imino-6-azauracil (3a),6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds - IR, 1H...

Design of Biosensors Based Transition-Metal Dichalcogenide for DNA-base Detection: A First-Principles Density Functional Theory Study

The main function purpose of nanobiosensors is to sense a biologically specific material and the kind of sensing platform and doping engineering has been an emerging topic and plays an important role in monolayer molybdenum disulfide (mMoS2). In this paper, we theoretically reveal the electronic structures of mMoS2 doped by 3d transition metals. Furthermore, adsorption of nucleic acid [Adenine ...

Thymonucleic Acid in Tumors**

THE ROLE OF THYMONUCLEIC ACID IN NORMAL CELLS Chromosomes and Genes Cytoplasmic Nucleic Acids Protein Synthesis Bacteria and Filterable Viruses THE ROLE OF THYMONUCLEIC ACID IN NEOPLASTIC CELLS The Significance of Nucleic Acids in the Somatic Mutation Theory of Etiology Chemical Evidence of Disturbance of Nucleic Acids in Tumors Histochemical and Cytochemical Evidence of Disturbance of Thymonuc...

The nucleic acid of African Horse-Sickness Virus

ADRIS--The Adverse Drug Reactions Information Scheme.

Under the Adverse Drug Reactions Information Scheme (ADRIS) data and knowledge relevant to the etiology of adverse drug reactions (ADRs) such as chemical structure of parent compounds, metabolites, covalent adducts, nucleic acid and protein sequences, protein structures, pharmaco-, toxico- and enzyme kinetics, pharmaco- and toxicodynamics, protein interactions, molecular pathways and complexes,...